A patient-centered, combination intervention to support adherence to HIV pre-exposure prophylaxis during pregnancy and breastfeeding: a randomized pilot study in Malawi

The intervention was integrated Next Step Counseling to identify relevant needs and help participants generate their own solutions for improving, facilitating, and sustaining well-being, sexual health, and drug adherence, as well as optional engagement of an adherence supporter. Study retention remained high at both three months and six months after initiation. There were no significant differences of adherence between the intervention group and control groups at three months or six months. Fewer than 1/3 of participants had confirmed adherence of >=4 doses/week.

Resource Details

Study Type
Pilot study, Randomized clinical trial (RCT)
Year
2024
Population
HIV-uninfected women, Pregnant Women
Author
Chi BH, Saidi F, Graybill LA, Phanga T, Mollan KR, Amico KR, Freeborn K, Rosenberg NE, Hill LM, Hamoonga T, Richardson B, Kalua T, Phiri S, Mutale W.

More Publications & Resources

Kenya Integrated Guidelines for Prevention, Treatment and Management of HIV, Sexually Transmitted Infections and Viral Hepatitis, 2026

Kenya Integrated Guidelines for Prevention, Treatment and Management of HIV, Sexually Transmitted Infections and Viral Hepatitis, 2026

Providing PrEP to Pregnant and Breastfeeding Women

Providing PrEP to Pregnant and Breastfeeding Women

Clinical Practice Guidelines for Providing PrEP for Pregnant and Breastfeeding Populations

Clinical Practice Guidelines for Providing PrEP for Pregnant and Breastfeeding Populations

Guidelines on Lenacapavir for HIV Prevention and Testing Strategies for Long-Acting Injectable Pre-Exposure Prophylaxis

Guidelines on Lenacapavir for HIV Prevention and Testing Strategies for Long-Acting Injectable Pre-Exposure Prophylaxis

PrEP and PEP Guidelines-Zambia

PrEP and PEP Guidelines-Zambia

PrEP Lenacapavir Implementation Guidelines

PrEP Lenacapavir Implementation Guidelines

Provider Training Toolkit on Use of Oral and Long-acting HIV PrEP: Lenacapavir-Focused Learning Pathway (Lessons 1-4)

Provider Training Toolkit on Use of Oral and Long-acting HIV PrEP: Lenacapavir-Focused Learning Pathway (Lessons 1-4)

Provider Training Toolkit on Use of Oral and Long Acting HIV PrEP

Provider Training Toolkit on Use of Oral and Long Acting HIV PrEP

Inclusion of Pregnant and Lactating People in the PURPOSE 1 Study: Efficacy, Safety, and Pharmacokinetics

Inclusion of Pregnant and Lactating People in the PURPOSE 1 Study: Efficacy, Safety, and Pharmacokinetics

Lenacapavir Provider Tools and Job Aids

Lenacapavir Provider Tools and Job Aids

PrEP Drug Interactions

PrEP Drug Interactions

Zambia PrEP Training Materials for Clinicians and Community Mobilisers

Zambia PrEP Training Materials for Clinicians and Community Mobilisers

No results found.